This study has shown that ascorbic acid and alpha-tocopherol are beneficial for the treatment of polycystic ovarian syndrome. Ascorbic acid and alpha-tocopherol contribute to PCOS therapy in rats. Daddy smear body weight, body temperature and blood sugar levels, testosterone and insulin were measured. Both AA and ACE increased the total antioxidant potential and reduced malondialdehyde levels. Both AA and ACE increased lean glucose, but had no significant effect on serum insulin levels. Mifepristone and lethrosol models were used and young and adult rats were randomly assigned to groups of six rats in a group. By providing information, we do not diagnose, treat, facilitate or prevent any disease or disorder. It is advisable to consult a licensed health care professional before any natural, integrative or routine treatment is started. This study has shown that AA and ACE are useful for PCOS treatment. The total antioxidant capacity and concentration of malondialdehyde have been analyzed. AA decreased testosterone levels, but ACE caused a slight increase. AA and ACE also reduce ovarian mass and especially dissolved ovarian cysts and uterine clogging.