Moringa oleifera leaf extract reduces hypertension by relieving vascular dysfunction and reducing oxidative stress in L-NAME hypertensive rats. Moringa oleifera leaf extract reduces hypertension by relieving vascular dysfunction and reducing oxidative stress. Conclusion: These results suggest that the antihypertensive effect of EMO in hypertensive rats with L-NAME can be mediated by relieving vascular dysfunction and oxidative stress and promoting endothelial vasorelaxation. In addition, MOE has shown antioxidant effects in hypertensive rats, as indicated by the suppression of O vascular production, decreased MDA values in plasma and thoracic aorta, and increased antioxidant activities of SOD and CAT. BACKGROUND: Improving the release of resistance arteries and reducing oxidative stress through the use of natural products are possible strategies for the prevention and treatment of hypertension. EMO reduced alteration of acetylcholine-induced relaxation and decreased hypersensitivity of adrenergic-mediated contraction in response to periarterial nerve stimulation and phenylephrine in isolated mesenteric artery beds. RESULTS: Rats treated with L-NAME had significantly elevated blood pressure and heart rate. The vasorreactivity of the mesenteric arterial bed isolated from the rat was determined by infusion pressure changes detected by a pressure transducer. Before undertaking any natural, integrative or conventional treatment, it is recommended to consult a licensed physician.