Discovery Studio – Taken together these results suggest

Taken together, these results suggest that peerarin has a hypoglycemic effect by reducing oxidative stress and improving mitochondrial function through AMPK phosphorylationregulation, which may be a potential therapeutic option for the treatment of diabetes. Other mechanism studies have shown that peerarin suppresses oxidative stress and improves liver mitochondrial lung function by increasing ATP production and activating AMPK phosphorylation. Hypoglycemic activity of perarin through modulation of oxidative stress and mitochondrial function via AMPK. In addition, oxidative stress and mitochondrial respiratory activity of the liver were investigated in rats with type I diabetes. We used streptozotocin-induced type I diabetic rats to observe the effect of puerarin on glucose metabolism. In addition, puerarin decreased fasting glucose and dietary glucose levels and improved glucose tolerance in type I diabetic mice. The results showed that puerarin increased glucose uptake by HepG2 and regulated the expression of genes related to glucogenesis. Finally, molecular docking was performed to predict the potential interaction of puerarin with AMPK using LibDock in Discovery Studio 2018. A pre-docking study showed that puerarin interacted with the AMPK activation site and enhanced phosphorylation. Glucose uptake in HepG2 cells was studied in vitro along with detection of glucogenesis gene expression by qPCR. Puerarin is widely used in cardiovascular diseases and vascular complications of diabetes mellitus. By providing the information contained herein, we do not diagnose, treat, cure, alleviate, or prevent disease or illness of any type. It is recommended that you seek the advice of a licensed health care professional before undergoing any natural, integrative or conventional treatment. In addition, ATP production has been investigated and AMPK phosphorylation has been determined using a Western blot. Hyperglycemia is the dominant phenotype of diabetes and a major cause of diabetic complications.