Fucoidan inhibits epithelial transition to mesquima by regulating the HIF-1α pathway in breast cancer cells under hypoxia. Western has shown that treatment with fucoidan significantly reduces the protein expression of the target genes HIF-1α and HIF-1. Under hypoxia, treatment with fucoidan inhibited the proliferation of breast cancer cells. Transilation and cure tests were performed to analyze the invasion and migration of human breast cancer cells MDA-MB-231. These data suggest that Fucoidan may inhibit EMT in human TNBC cells by decreasing the HIF1-α signaling pathway. Fucoidan has also suppressed the invasion and migration of MDA-MB-231 cells. In addition, overexpression of HIF1-α protected cells from migration suppression and fucoidan invasion. Before undertaking any natural, integrative or conventional treatment, it is recommended to consult a licensed physician. By providing the information contained in this document, we do not diagnose, treat, cure, mitigate or prevent any type of disease or medical condition. More than 500 pages with alternatives and information about natural medicine.
Your Resource For Current Health News