STUDY DESIGN – The purpose of this study was to determine

The purpose of this study was to determine the effect of celastrol on the resistant cell line of vinocrystalline cancer and to elucidate the mechanism of cell apoptosis induced by the disaster. Therefore, our study investigated the apoptotic effect of celastrol and the mechanism of this drug acts on a cancer cell line resistant to Vincentian crystals. METHODS AND RESULTS: Our study showed that celastrol causes apoptosis of cancer cells in the head and neck through mitochondrial and fiber-mediated pathways. STUDY DESIGN: Celastrol has been added to the resistant vinocrystalline cancer cell and immunoreactive proteins have been detected. Cell apoptosis mediated by Celastrol decreased the expression of Bcl-2, not Bcl-xL. However, it is not yet known whether this herbal drug has a positive effect in patients with vinocrystalline resistant oral cancer. Celastrol is a pentacyclic triterpenoid isolated from the Chinese medicinal plant Trypterygium wilfordii, which has therapeutic potential in several diseases. CONCLUSION: Celastrol could become a useful treatment for oral cancer with MDR. By providing the information contained in this document, we do not diagnose, treat, cure, mitigate or prevent any type of disease or medical condition. More than 500 pages with alternatives and information about natural medicine.