The pro-inflammatory response of cisplatin was reduced by PIC therapy, as demonstrated by the suppression of kappa-B nuclear factor activation and the subsequent reduction in tissue level of interleukina-1β, tumor necrosis factor-α, cyclooxygenase-2, and inducible nitric oxide synthase. Attenuated reduction of Nrf2 expression and relative mRNA levels of antioxidant enzymes: haemoxygenase 1, cysteine ligase catalyst and modifying subunits, and superoxide dismutase and glutathione S-transferase activities. In addition, the role of PIC in the activation of Nrf2 and the subsequent induction of antioxidant enzymes and their possible interference with the nuclear factor kappa-B was examined. PIC reversed the increase in nephrotoxicity markers induced by cisplatin and restored normal renal ultrastructure. Before undertaking any natural, integrative or conventional treatment, it is recommended to consult a licensed physician. By providing the information contained in this document, we do not diagnose, treat, cure, mitigate or prevent any type of disease or medical condition. Piceatannol protects against cisplatin-induced nephrotoxicity. More than 500 pages with alternatives and information about natural medicine. PIC suppressed cisplatin-induced apoptosis by reducing the expression of p53 and the activity of cytochrome C and caspase 3.
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