CoQ10 supplements effectively reduce pain, anxiety and brain activity, mitochondrial oxidative stress and inflammation. Taking CoQ10 supplements relieves pain in patients with fibromyalgia receiving pre-gabaline therapy, thus reducing brain activity and mitochondrial dysfunction. Coenzyme Q10 relieves pain in patients with fibromyalgia receiving pre-gabaline therapy, which reduces brain activity and mitochondrial dysfunction. However, it had no effect on mitochondrial oxidative stress and inflammation. It is recommended that a licensed physician be consulted prior to any natural, integrative or routine treatment.