Cinnamic aldehyde improves the apoptotic effect of oxaliplatin and reverses the epithelium-mesenchymal transition and stem cells of hypoxic colon cancer cells. Oxaliplatin has been widely used in clinical chemotherapy of tumors, whose failure in treatment is mainly due to low susceptibility resulting from intrinsic or acquired resistance to drugs in tumor cells. These consequences have revealed the potential therapeutic value of cinnamic aldehyde and have provided new ideas for improving the sensitivity of oxaliplatin in the treatment of CRC However, cinnamic aldehyde has increased the healing effect of oxaliplatin by promoting apoptosis in vitro and in vivo. Cinnamaldehyde is obtained from Cinnamomum cassia with an inhibitory effect against tumor types. Before undertaking any natural, integrative or conventional treatment, it is recommended to consult a licensed physician. By providing the information contained in this document, we do not diagnose, treat, cure, mitigate or prevent any type of disease or medical condition. Microecological hypoxia is one of the most important pathological characteristics of solid tumors, closely related to tolerance to radiochemotherapy and poor prognosis. More than 500 pages with alternatives and information on natural medicine.