To use sesamele as a chemotherapeutic agent in the prevention and treatment of cancer, it is necessary to know the molecular targets of sesamele and the mechanisms underlying the fight against it. There are many signs that sesamele has strong anti-cancer properties in vitro and in vivo. Thus, there are many signs that sesamele has strong anti-cancer properties in vitro and in vivo. The therapeutic potential of sesamol is widely studied and it is proved that sesamele acts as a regulator of metabolism with antioxidant, antimutagenic, hepatotoxic, anti-inflammatory, anti-aging and chemoprophylactic properties. Here is a complete overview of anticancer activity in vitro and in vivo sesamol in various cancer cell lines and animal models. The mechanisms of action of sesamol for the development of its antitumor activity are described. Several studies have shown that sesamol has a strong anti-cancer effect. The protective role of sesamol against oxidative stress has been analyzed in terms of its function of radical retention and its potential to reduce lipid peroxidation. The ability of sesamol to regulate apoptosis and various phases of the cell cycle is also described.