Oxidative stress was significantly reduced, even after treatment with formonetine, as well as increased expression of SIRT1 in the renal tissues of diabetic animals. DESCRIPTION: Formonononetine is a potential molecule that increases the expression of SIRT1 in the renal tissue of diabetic patients. Formonetine reduces kidney damage in type 2 diabetic rats. KEY CONCLUSIONS: Treatment with formononetine for 16 weeks to control hyperglycemia and insulin resistance in diabetic animals. Formonononetine is an effective molecule for controlling kidney disease in type 2 diabetes mellitus. Therefore, formononetine is an effective molecule for controlling kidney disease in type 2 diabetes mellitus. According to several reports, the reduction of SIRT1 expression in renal tissues is a key factor in the development of renal disease in diabetics, as its reduction in tissues is associated with excessive formation of ROS. Treatment with formonononetine has also improved creatinine clearance in diabetic animals. Treatment with formonetine reduces the concentration of creatinine in the blood, urea nitrogen in the blood and increases the concentration of albumin. Before undertaking any natural, integrative or conventional treatment, it is recommended to consult a licensed physician. Formonononetine was administered orally to diabetic animals at a dose of 10. Chronic hyperglycemia leads to renal disease in diabetics because excessive reactive oxygen species and advanced glycation end-products are formed that are reflected in glomerulosclerosis, tubular atrophy and interstitial fibrosis.