The idea that lipid peroxidation is a “starting point” for acne is not new; here we discuss nearly 50 years of lipid peroxidation theory and give a historical perspective of current studies and clinical implications. In addition, we propose a new hypothesis that lipid peroxidation can increase sensitivity to comorbid depression and acne anxiety. Lipid peroxidation may precede acne formation and cause increased susceptibility to comorbid depression and anxiety. Clinical effects of lipid peroxidation on acne vulgaris: old wine in new bottles. New research on systemic oxidative stress in acne provides more information on the axis of brainwashing. In fact, lipid peroxidation itself has been shown to be a coincidence causing an inflammatory cascade of acne. New studies have shown that patients with acne experience an increase in oxidative skin and systemic stress. The latest results also suggest possible approaches to the treatment of acne with specific nutrients, nutritional changes and oral and topical interventions. In recent years there has been an increasing emphasis on the degree of oxidative stress in the pathophysiology of acne. Acne vulgaris is a common dermatological disorder often accompanied by depression, anxiety and other psychological consequences. Before carrying out any natural, integrative or conventional treatment, it is recommended that you consult a licensed physician. By providing the information in this document, you should not diagnose, treat, cure, alleviate or prevent any disease or medical condition. More than 500 pages of alternatives and information on natural medicine.