Prenatal but not postnatal use of curcumin prevents neuromorphological and cognitive changes in rats with C65Dn-Down syndrome Prenatal but not postnatal use of curcumin prevents neuromorphological and cognitive changes in rats with C65Dn-Down syndrome: The positive effect of prenatal application of curcumin to rats with DM suggests that it may be a therapeutic strategy to treat cognitive impairment in rats with DM. The long-term effects of prenatal curcumin were studied in another cohort of 44 TS and CO rats between PD30 and PD45. Long-term neuromorphological and cognitive effects were studied in 45 rats between PD60 and PD90. The information contained in this document does not diagnose, treat, facilitate, or prevent any disease or illness. It is recommended that you consult a licensed health care professional before starting any natural, integrative, or routine treatment. Kurkumin promotes neurogenesis, learning and memory. In PD2, changes in neurogenesis, cell counts and brain mass in 30 puppies TS and CO have been analyzed.