We found that AD reduced gene expression and protein level in MDM2 ased p53 protein expression, which was determined by qPCR and Western blot tests. MDM2 as a target for in vitro deletion of prostate cancer cells with ellagic acid. By providing information, we do not diagnose, treat, relieve, or prevent any disease or disorder. It is recommended that you seek advice from a licensed health care professional before conducting natural, integrative or routine treatment. We have concluded that AD has partially suppressed PCa cells in vitro by regulating MDM2. Despite the available treatments for APC, a significant number of patients retreat when the disease becomes hormonally independent.