In general, the data suggest that FPhas an antidepressant effect and relieves neuroinflammation by inhibiting the signal transduction of CASP-11-dependent pyroptotic induced over-activated microclinations in the rat hippocampus to treat resinitis. Thus, GSDMD-mediated pyroptose in activated microglia is an unprecedented inflammatory mechanism of depression and a unique therapeutic option for depression relief in FP. In addition, VX-765, an effective and selective inhibitor of CASP-1 activation, has reduced the expression of the proteins associated with inflammation and pyrotosis in reactivated N9 and promoted synergistic inhibition of FP pyroptose. The information contained in this document does not constitute a diagnosis, treatment, mitigation or prevention of any disease or medical condition. It is recommended to seek advice from a qualified medical professional before embarking on any form of natural, integrative or traditional treatment. Over 500 pages of alternatives and information about natural medicine. Modelling of molecular coupling predicted that PF will interact with the C GSDMD terminal.