In addition, a single-sided rat model of renal fibrosis with ureteral obstruction was created to study the antifibrosis effect of emode combined with in vivo HGF can offer ation with HGF can offer a new treatment option for renal fibrosis. For example, emodin in combination with HGF may be a new treatment option for renal fibrosis. In addition, we have found that combination therapy has better antifibrosis effects in vivo than emodin or FHD. Emodin slows down renal fibrosis by regulating the signaling pathway HGF and TGFβ-Smad. Emodin or HHD has been shown to inhibit the development of renal fibrosis. Overtones: Kidney cystic fibrosis is a common form of chronic renal failure, which can lead to the final stage of renal failure. However, the antifibrosis effect of Emodin in combination with HRC remains uncertain. Conclusion: These data have shown that emodin plus HGH has a better antifibrotic effect than emodin or HGH. It is recommended to seek advice from a licensed physician before starting natural, integrative or routine treatment. In addition, the increased expression of collagen II caused by HGF has been enhanced by emodin. By providing this information, we do not diagnose, treat, relieve or prevent any disease or condition. The expression of gene and protein in HK2 cells was detected with qRT-PCR or Western blot. Results: HGF significantly increased the expression of collagen II in HK2 cells treated with TGFβ.