Eckol suppresses PM 2.5-induced damage in skin keratinocytes via the MAPK signaling pathway. Western blot analysis showed that PM promotes apoptosis-related proteins and activates the MAPK pathway, whereas Eckol protects cells from apoptosis by inhibiting the MAPK pathway. In this study, we tried to elucidate the mechanism underlying the protective action of Eckol, a chlorotannin extracted from brown algae, on human HaCaT keratinocytes against particle-induced cell damage. Thus, our results showed that inhibition of Eckol particle-induced cell apoptosis occurs through the MAPK signaling pathway. Eckol inhibits PM 2-induced damage in skin keratinocytes.5 In conclusion, Eckol can protect skin HaCaT cells from PM-induced apoptosis by inhibiting ROS formation. Experimental data show that excess lipids, proteins, and DNA damage ROS and cause mitochondrial dysfunction. By providing the information contained herein, we do not diagnose, treat, cure, alleviate, or prevent any type of disease or medical condition. It is recommended that you seek the advice of a qualified health care professional before beginning any natural, integrative, or traditional treatment. It manifests in cancer, aging and skin lesions. This conclusion has been supported by extensive research on MAPK inhibitors.