Thus, AD has a significant effect on the improvement of cholesterol content in serum in naturally aging perimenopausal rats through estrogen receptors of the signaling pathway, and can be used as a dietary supplement for perimenopausal women to reduce the risk of cardiovascular disease. Cranberry anthocyanine improves serum cholesterol levels in old perimenopausal rats, signaling estrogen receptor pathways. As women age, they are at increased risk of developing perimenopausal syndrome, which is harmful to their physical and mental health. It is recommended that a licensed physician be consulted prior to any natural, integrative or routine treatment. When providing information contained herein, you should not diagnose, treat, cure, alleviate or prevent any illness or health condition. Over 500 pages of alternatives and natural medicine information. This site is for information purposes only.