Eight weeks of oral supplements reduce depression, anxiety and sleep disturbance. The supplements have improved depressive anxiety and sleep quality as well as Pro-BDNF circulation levels without significant changes in circulating BDNF levels. We investigated whether the treatment of depression, anxiety, sleep and eating disorders improved after eight weeks of supplementation in patients with obesity or overweight on a low-calorie diet. Hericium erinaceus improves mood and sleep in obese and overweight patients. Epidemiological evidence suggests that obese people are at greater risk of developing affective disorders. The relationship between obesity and mood disorders is a two-way street. Two different enzyme-linked immunosorbent assays were used to distinguish between circulating pro-DNF and BDNF values. It is recommended to consult a licensed physician before performing any natural, integrative or routine treatment. By providing the information contained in this document, we do not diagnose, treat, treat, mitigate or prevent any disease or health condition. More than 500 pages of alternatives and natural medicine information.