The hepatoprotective effect of flaxseed and flaxseed protein on ethanol-induced hepatotoxicity was studied in adult Wistar rats. These results imply the improvement of the effect of flaxseed and its protein on ethanol-induced hepatotoxicity. Flaxseed and its proteins have significantly prevented increased plasma markers of liver damage, decreased lipid peroxidation, attenuated changes in antioxidant enzymes, and suppression of histopathological signs of liver damage. Improved effect of flaxseed and flaxseed protein on ethanol-induced hepatotoxicity. The results of this study suggest that inclusion of flaxseed or flaxseed protein in food formulations may prevent hepatotoxicity and improve the overall quality of life of alcoholics. This study also examines the benefits of including flaxseed as a staple food. This study examines the effectiveness of flaxseed and its proteins in protecting the liver from ethanol-induced hepatotoxicity. The hepatoprotective effect of flaxseed and its protein was comparable to that of ICC Since alcohol withdrawal is a demanding task, it is necessary to formulate potential hepatoprotective agents to avoid alcohol-related liver damage. Alcohol consumption is recognized worldwide as the leading cause of liver damage and has contributed to 44% of deaths from liver disease. PRACTICAL APPLICATIONS: Globalization and increasing purchasing power make alcohol consumption an integral part of social life and gradually transform it into dependence.