Potentiation Taken together, we found an optimal oral delivery system that promotes oral administration of eucalyptol to exert a protective effect on hyperglycemia-induced vascular endothelial damage in rats. Hyperglycemia is a major pathophysiological factor in diabetes mellitus associated with vascular endothelial damage, which is mainly due to a change in the balance between ROS production and removal. In addition, PK data showed that the nanotransporter promotes oral intake of eucalyptol. In addition, the model and study verified the mechanism of eucalyptol in promoting Nrf2 and HO-1 and decreasing Keap1 expression. Eucalyptol was found to have a specific antioxidant action that stimulates the secretion of endogenous antioxidant enzymes against ROS. By providing the information contained herein, we are not diagnosing, treating, curing, alleviating, or preventing any disease or illness. However, the volatility, instability, and low solubility of eucalyptol in water limit its pharmacological activity. It is recommended that you seek the advice of a licensed health care professional before resorting to natural, integrative or conventional treatments. Over 500 pages of information on alternative natural remedies. A thin lipid film dispersion method was used to prepare ELN.