We performed cell proliferation assay, cell invasion assay, gelatin zymography, wound healing assay and Western blotting to determine whether anthocyanins can inhibit A549 cell proliferation, invasion and angiogenesis. CONCLUSION: This study shows that anthocyanins isolated from the fruits of Vitis Pulliat coignetia inhibit the proliferation, migration and invasion of cancerous tumors that are involved in cancer metastasis. We investigated whether anthocyanins can inhibit proliferation, invasion and angiogenesis of A549 human lung cancer cells, which play a key role in cancer metastasis. Anthocyanins isolated from the fruits of Vitis pulleata coignetii inhibit cancer proliferation, migration, and invasion. Results: AIMs did not inhibit cancer cell proliferation in A549 cells. In addition, MMS suppressed cancer migration and invasion by suppressing the expression of MMP-2 and MMP-9. This study provides evidence that MMP-2 may have anticancer effects in human lung cancer. Purpose: Anthocyanins belong to a class of flavonoids that have antioxidant and anti-inflammatory effects and have been reported to have anticancer effects. In providing the information contained herein, we do not diagnose, treat, cure, alleviate, or prevent disease or illness of any type. It is recommended that you seek the advice of a qualified health care professional before beginning any natural, integrative, or traditional treatment. Asian Cancer Prev Pac J. Over 500 pages of information and natural healing alternatives.