Interestingly, INS treatment reduced APAP-induced liver damage and oxidative stress, suppressed NLRP3 inflammasome activation, and reduced inflammatory cytokine levels. Results: The results showed that compared with the control group, the serum ALT, AST and ALP levels of APAP-induced rats were significantly increased, followed by histological liver damage and hepatocyte apoptosis. In vitro studies showed that NAS treatment significantly reduced BRL-3A cell viability, oxidative stress and inflammation. Synomenin reduces acute liver damage caused by acetaminophen. Inflammatory factors and oxidative stress index were measured by ELISA. By providing the information contained herein, we do not diagnose, treat, cure, alleviate, or prevent any type of disease or medical condition. It is recommended that you seek the advice of a qualified medical professional before beginning any natural, integrative, or traditional treatment. Introduction: Liver disease is common and often life-threatening.