Overall, our data suggest that Cur attenuates the metabolic features of hepatic steatosis and insulin resistance in HFD-fed obese mice, which may be related to modulation of gut microbiota composition and metabolites. Curcumin attenuates diet-induced hepatic steatosis and obesity due to modulation of gut microbiota in rats. Dietary curcumin reduces body fat, hepatic steatosis, and circulating lipopolysaccharide levels, and improves insulin sensitivity in HFD rats. Changes in the dominant bacterial genera showed a strong correlation with metabolic parameters associated with obesity in HFD-fed mice. Curcumin reduced liver steatosis and obesity caused by a high-fat diet. We hypothesize that the gut microbiota may be a potential therapeutic target for curcumin-induced metabolic benefits. Before starting any natural, integrative or conventional treatment, it is recommended that you seek the advice of a licensed physician. By providing the information contained herein, we are not diagnosing, treating, curing, alleviating, or preventing any disease or medical condition. Over 500 pages of information and alternatives to natural medicine.