Adding polycosanol reduced the ApoB level and increased the expression of LDL receptors, but did not affect the ACAT2 level in the liver in hypercholesterol rats. Polycosanol inhibits cholesterol synthesis by activating AMPK in hypercholesterol rats. Polycosanol reduces cholesterol synthesis by activating AMPK in hypercholesterol rats. This study was conducted to study the effect of polycosanol on hypercholesterol rats caused by a diet rich in fats and cholesterol to prove its hypocholesterol effect. Finally, we suggest that polycosanol supplements cause antihypercholesterolemia by inhibiting cholesterol biosynthesis, absorption of LDL cholesterol and cholesterol secretion. By providing the information contained in this document, we do not diagnose, treat, cure, facilitate or prevent any disease or health condition. We recommend that you consult a licensed physician before performing any natural, integrative, or routine treatment. More than 500 pages of alternatives and information on natural medicine. This site is for information purposes only.