OBJECTIVE: To compare the efficacy, safety and tolerability of 75 mg of pycnogenol taken orally twice a day with placebo combined with a triple combination and broad-spectrum sunscreen to treat facial melasma. CONCLUSION: Picnogenol is well tolerated and increases the effectiveness of broad-spectrum sunscreen and triple combination sunscreen in the treatment of facial melasma in women. Picnogenol is well tolerated and increases the efficacy of broad-spectrum sunscreen and triple combination sunscreen in the treatment of facial melasma in women. Methods: A randomized, double-blind, parallel, placebo-controlled study was conducted between May 2019 and November 2019 on 44 women with facial melasma in one center. It is recommended that a licensed health care provider be consulted before any natural, integrative, or routine treatment begins. BACKGROUND: Melasma may be insoluble during treatment, and relapses are common. Picnogenol has proven effective in treating melasma. The information contained in this document does not diagnose, treat, relieve, or prevent any disease or illness. There are more than 500 pages of alternatives and information about natural medicine.