The purpose of this work was to demonstrate the role of the crock in the relief of motor-cognition disorders caused by MK-801 in the model of schizophrenia in newborn rodents, as well as to illustrate the molecular mechanisms underlying them. Conclusions: In general, in the MK-801-induced model of schizophrenia, crocine has a neuroprotective effect through the regulation of SIRT1 and the subsequent expression of BDNF in the hippocampus. Crocine relieves symptoms of schizophrenia in rats by regulating the silent information regulator 1 and the neurotrophic factor in the brain. Learning disabilities and motor deficits caused by MK-801 treatment have also been reduced by the administration of crocuses. Cocaine had a neuroprotective effect on MK-801-induced model of schizophrenia in rats. Motor training and coordination, locomotor and research activity, as well as spatial memory were studied using the Rotarod test, field pen test and Morris test for water maze. Cocaine is a water-soluble saffron carotene with a strong neuroprotective effect. BACKGROUND: In newborn rats, MK-801 treatment can cause schizophrenic-like symptoms. By providing this information, we do not diagnose, treat, relieve or prevent any disease or condition. It is recommended that you consult a licensed health care provider before starting any natural, integrative or routine treatment. The relative amounts of mRNA and proteins in the participating genes have been analyzed by qRT-PCR or Western blot. More than 500 pages of alternatives and information about naturopathy have been analyzed.
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