In addition the physiological responses observed in the

In addition, the physiological responses observed in the gills correlate with the above observations and help to decipher a possible molecular mechanism underlying PS-MP induce ROS-mediated apoptotic responses in a dose- and time-dependent manner in zebrafish. Polystyrene microplaques induce apoptosis through the ROS-mediated p53 pathway in zebrafish. We showed that PS-MPs significantly regulate the transcriptional pattern of tnfa and ptgs2a, which are important genetic markers in the mechanism of inflammation. Recent scientific reports have documented their toxic effects at the cellular and organ level, but the underlying molecular mechanism of their toxicity remains unclear. In addition, exposure to PS-MPs increased the expression of p53, gadd45ba, and casp3b, leading to apoptosis. By providing information herein, we are not diagnosing, treating, curing, alleviating, or preventing any disease or medical condition. PS-MPs also significantly inhibited neurotransmission in zebrafish. Before starting any natural, integrative or conventional treatment, it is advisable to seek the advice of a qualified professional. The expression profile of the antioxidant genes cat, sod1, gpx1a, and gstp1 was significantly altered.