Our results suggest that quercetin and isorhamnetin promote metabolism, detoxification, and excretion of B[a] P thereby enhancing its antigenotoxic effect and protecting against B[a]P-induced cytotoxicity. Quercetin and isoramnetin increase the expression level of genes and proteins of phase I, II and III enzymes involved in xenobiotic detoxification. Quercetin and isoramnetin attenuate benzo[a]pyrene-induced toxicity by modulating detoxification enzymes through the AhR and NRF2 pathways. Quercetin and its metabolite, isoramnetin, reduced benzo[a]pyrene-induced cytotoxicity, whereas the metabolite myelianin did not reduce benzo[a]pyrene-induced cytotoxicity. In this study, we examined the molecular mechanisms involved in the cytoprotective effects of quercetin and its metabolites against benzo[a]pyrene in terms of detoxification. After oral quercetin administration, quercetin metabolites, isoramnetin and myelianin, were more concentrated in human plasma than quercetin. In addition, quercetin and isorhamnetin reduced intracellular levels of BPDE-DNA adducts. By providing the information contained herein, we are not diagnosing, treating, curing, alleviating, or preventing any disease or medical condition. Quercetin is a flavonoid found in abundance in fruits and vegetables. Before beginning any natural, integrative, or traditional treatment, it is advisable to seek the advice of a qualified medical professional. The formation and excretion of BPDE occurs during the detoxification of xenobiotics. Over 500 pages of information and alternatives to natural medicine.